Hi @mgreen616 I am sorry to read about your husband's medical demands. Really tough, difficult stuff for him and you all, too. I am Scott and I add my welcome to you here at Mayo Connect. My wife had brain cancer and I was her primary caregiver during her 14+ year war with it. We have two children (grown) and two young grandsons who also had to deal with seeing my wife struggle with this terrible disease.

As far as clinical trials, I suggest the site below. It is the NIH's clearinghouse on clinical trials for cancer. It can be a very tool at times.
https://www.cancer.gov/about-cancer/treatment/clinical-trials/what-are-trials/where/clinical-center
Over the course of my wife's journey her tumor changed dramatically from time to time with no warning nor timetable. She often flummoxed even her medical team with how it changed, grew, or held off at times.

I know it will be of little comfort, but I will tell you our grandsons learned a great deal about how to interact with people with special/different needs than their own as they dealt with my wife's illness and its many permutations. They came to be quite empathetic and understanding of how disease can change, but at times not change, a loved one. Sometimes the changes were harder for our adult children to deal with than our grandsons. Odd I know, but in some cases young may be a benefit is what we saw.

I also remember times of change were the most challenging so I hope you get some time of stability.

Strength, courage, and peace