Hello Derbetal. It is good hearing from you. Yeah, the antibiotics used to treat mac can be a bear to handle. There are various ways to treat mac; the 'Big 3' is not the only route. You can click on my photo icon and read how I was successfully treated. It all would depend on your suseptibility test to show what other meds may work for you. There are also newer meds that are nebulized which sends the meds straight to your lungs., i.e. arikayce and clofazimine. These supposedly bypass being in your entire body and thus affecting other organs. Plus, they target the infected area, the lungs. You may want to ask your dr about alternate meds to treat you with. Do you have a copy of your suseptibility tests from the lab? If not, get it. This will help you to be in charge of your health. I have a file just for my sputem lab results and the suseptibility test going back to 2013. There are many reasons to do this, and I plan to start a new conversation about that. Good luck tomorrow with your dr appt. Reminder: while there, ask for a printed hard copy of all your sputem lab tests and the suseptibility test. Would you mind coming back on here and sharing what you have learned after your dr visit?