OMG I'm tearing up reading your discussion with @afirefly. I thought I'm the only person dealing with this progressive nueropathy through Mayo. I can identify with most of your stated conditions, the fears of a loss of independence, what health complications are ahead of me and the lack of an effective therapy. My neuropathy is also idiopathic - no known cause. It's many years into the progression. It started about a decade ago with numb/tingly toes and then feet a few years later. Now, my toes curl under as I walk, tripping me up; so I have to wear good fitting shoes. One year ago, I underwent Lumbar Decompression Surgery, L3 to L5, both left and right, in an attempt to get back some nerve/muscle control of my left foot. Several months post surgery, I noticed both feet and legs were equally worse. It does appear that I healed and recovered remarkably well from the surgery. I don't notice any restoration in leg or feet feeling yet, but hopefully in the second year I may. I used various strategies to maintain my fiercely guarded independence, especially during Covid-19. Unfortunately, the progressive nature of neuropathy is making every aspect of life more challenging. Like you, I don't experience pain, except from the muscle cramps, which nothing seems to help. Thankfully, I go through weeks of relative less cramps to weeks of intense ones. I keep getting weaker and find it more difficult to exercise. Now that my neuropathic nerve/muscle degradation involves not just my feet, ankles and legs, but my abs, chest and arms; I'm experiencing heart and other, seemingly unassociated complications.

Question: Are there other conditions/diseases that can cause these kinds of symptoms and is there really any effective interventions or therapies?