It took me 2 or 3 courses of targeted oral antibiotics, plus 28 days of inhaled Tobramycin, to beat down the pseudomonas. This was after almost a whole winter on an assortment of other antibiotics for "chronic bronchitis." After that I did an 18 month course of the "Big 3" antibiotics to beat down (but not completely eradicate) MAC. Now I am on 7% saline nebs, which I hope are keeping both from growing again.
Sue