Hello @gregg911, Welcome to Mayo Clinic Connect. My PMR is currently in remission but I've been on prednisone twice and was aware of a lot of different side effects but was not aware that it can cause a reduction in white blood cells (lymphocytes). I do know that in general prednisone can lower your immunity and thus make it easier for infections, etc.. There is another discussion you may be interested in reading through and meeting other members with PMR while we wait to see if other members have suggestions for you.

PMR Anyone?: https://connect.mayoclinic.org/discussion/pmr-anyone/

I did find some information that speaks to having low white blood cell count --- Excerpt from following article - "While no specific foods or diet changes are proven to increase production of white blood cells, if you have low WBC (leukopenia), it is very important to practice good hygiene, hand-washing, and food safety practices. Neutrophils are the cells that fight bacterial infection." -- White Blood Count & Diet: https://www.oncologynutrition.org/erfc/eating-well-when-unwell/white-blood-count-diet

@alanbruce @rolandhp @reagan1mc @beryl and other members have shared information about PMR and may have some suggestions for you.

Has your doctor or rheumatologist provided any suggestions to help with the low lymphocytes number?