I don't know. It is a simple sugar and I think the dosage without infection is half a teaspoon a day and 1 teaspoon a day if there is infection. There is a question section for the product on Amazon where you can ask. I found the reviews very helpful on how to use, too. Even though I don't get infections anymore, I take 1 teaspoon daily in 4 oz water at noon just to be on the safe side. I use the product that comes in a white bag with orange person on it. It was life changing for me.

@fdan and @cdink1941, welcome to Mayo Clinic Connect

D-mannose supplements should be used with caution if you have diabetes. It may make it harder to control your blood sugar.
High doses of D-mannose may cause kidney damage.

Here's additional information:
- Can D-Mannose Treat or Prevent UTIs? https://www.healthline.com/health/d-mannose-for-uti

In short, more research needs to be done, but D-mannose appears to be a promising nutritional supplement that may be an option for treating and preventing UTIs, especially in people who have frequent UTIs. Always tell your doctor about any supplements you are taking, including natural ones and those bought without a prescription.