@testladyI am so sorry you have MAC added to your lung cancer. Statistically that happens to certain women. In my family the MAC has been first. I would guess you are already fatigued by your cancer. Adding the Big 3 to that I would think would be a double whammy. I have had similar exhaustion which is typical, especially when Arikayce was added to my treatment. I totally get it when you say that some days you can barely move. Quality of life vs quantity of life has been an ongoing discussion in my home. Only you can decide that for yourself. Mindfulness has been suggested plus of course maintaining good and adequate nutrition. I will keep you in my thoughts and prayers. The headaches can be debilitating. Many people on this forum have said that if you can continue for a month with the side effects it should improve, and those side effects will become less in severity. Please share with your oncologist and pulmonologist/infectious disease doctors the symptoms you are having. They should be able to advise you about MAC treatments. You already have proven how very tough you are given that you have persevered for nine and a half years albeit symptom free. Wishing the best for you! irene5