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jrangel1 (@jrangel1)

PMR and Cancer

Polymyalgia Rheumatica (PMR) | Last Active: Aug 3, 2020 | Replies (6)

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Hello @johnbishop .. thank you for responding to my post as it's important to raise awareness of cancer symptoms similar to PMR. Your article infers that PMR caused the cancer. It's the other way around; cancer manifested itself in PMR symptoms of bilateral joint pain with raised CRP and Sed rates. My rheumatologist confirmed this correlation as well as my oncologist at MSK. Furthermore, it was known by all my doctors throughout my cancer treatment, although not common at about 10-20%. My symptoms disappeared entirely after chemo was completed. I never had PMR to begin with; just the symptoms where cancer was the culprit.
I'm unable to attach an article as a new member, but google pulmonologyadvisor – paraneoplastic-syndromes-associated-with-lung-cancer and you should find it. Hope this helps. Best.
Rheumatologic system: Numerous autoimmune disorders may include polymyositis-dermatomyositis, cutaneous vasculitis, hypertrophic pulmonary osteoarthropathy, Raynaud’s phenomenon, overlap syndrome, systemic lupus erythematosus, polymyalgia rheumatica, and Still’s disease.

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Replies to "Hello @johnbishop .. thank you for responding to my post as it's important to raise awareness..."

I don't worry too much about cancer but there are many diseases which masquerade as PMR. My understanding is that PMR is diagnosed if everything else is ruled out. However, most doctors don't rule out everything else and call it PMR when there is a rapid response to prednisone. Then there is the misconception that if the pain responds quickly to prednisone that confirms PMR. I have had neurological problems that responded well to prednisone. Many types of inflammatory arthritis and degenerative arthritis respond too. My rheumatologist just said many types of pain respond to prednisone.

It would be nice if the diagnostic criteria for PMR was more precise. Even pain associated with prednisone withdrawal and adrenal insufficiency mimics PMR. I have found it difficult to know if PMR is in remission or not.

I'm glad they caught your cancer.

@jrangel1 is this the link you wanted to post?

Paraneoplastic Syndromes Associated with Lung Cancer (ectopic Cushing’s syndrome, SIADH, hypercalcemia of malignancy,Lambert-Eaton myasthenic syndrome (LEMS), paraneoplastic limbic encephalitis, paraneoplastic cerebellar degeneration, paraneoplastic opsoclonus-myoclonus, dermatomyositis): https://www.pulmonologyadvisor.com/home/decision-support-in-medicine/pulmonary-medicine/paraneoplastic-syndromes-associated-with-lung-cancer-ectopic-cushings-syndrome-siadh-hypercalcemia-of-malignancylambert-eaton-myasthenic-syndrome-lems-paraneoplastic-limbic-encephaliti/