@rollinsk I often ask myself the same thing. I am in major depression right now, and I feel like I've been on every medication and tried almost every modality and nothing has helped me. Still, though, I have had relief for many years. When Prozac did work for me, I was in remission for 13 years. I did have some days where I felt more depressed, but not the heavy, raw hell I am going through right now. I hope you, too, find some relief.