@lorirenee1 You are right! The thing they said might help Linda was a drug (you may have heard of it) called herceptin. And I am pretty sure if they had just given her the herceptin she would have been fine, i.e. probably no PN. But they said "Well, all the clinical trials were done with herceptin administered with both carboplatin and taxotere" therefore they would only give it in that combo. From what I know now both of those other two chemo drugs definitely cause neuropathy in many people, especially the taxotere, but both for sure. Funny thing (well not funny at all really) after Linda refused to complete the chemo and we got back to Tennessee from San Diego, her oncologist here said if she wouldn't take it any other way, she would agree to give her herceptin without the other two. We gave each other a knowing wink/nod and definitely refused the offer, and we decided never again agree to anything out of hand with that bunch. Harumph!!! 😠 (Can you sense any disenchantment with the cancer establishment here?)