Hi @avmcbellar in addition to RALA Linda and I take a number of things to help boost our mitochondria, which as you probably know, are prevalent throughout your body (literally in the trillions) and are responsible for the body's energy production. One of these is Acetyl L Carnitine (ALC). We take 2 500mg caps together each day with food. We take the RALA 15-30 minutes before this because it is supposed to aid the ALC. What I found out the ALC does is it helps your mitochondria burn fat and create more energy — especially for your muscles and brain. ALC has two main benefits: It shuttles fuel (in the form of fatty acids) to your muscle mitochondria, which ramps up your energy production and can increase endurance, and it also boosts brain power. If you google "r lipoic acid and acetyl l carnitine" you will find a number of articles which discuss the benefits of taking these 2 in conjunction with one another. The reason we take the two 500mg pills together is that I read (and this is purely from memory from a year ago) that your digestive system's enzymatic action will counter it to some extent so you need to take enough to still be effective, hence the 1000mg all at once and not divided into a 500mg dose twice a day. Best, Hank