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← Return to Anastrozole's effect on TSH Thyroid level ???
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Anastrozole's effect on TSH Thyroid level ???
Breast Cancer | Last Active: Sep 7, 2020 | Replies (15)Comment receiving replies
Hi @katrina123, the FDA product monograph states (page 7) https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020541s016lbl.pdf
"In multiple daily dosing trials with 5 and 10 mg, thyroid stimulating hormone (TSH) was measured; there was no increase in TSH during the administration of ARIMIDEX (anastrozole). ARIMIDEX does not possess direct progestogenic, androgenic, or estrogenic activity in animals, but does perturb the circulating levels of progesterone, androgens, and estrogens."
I'm tagging fellow members @dorisena @shelleyc @kathyomaha55 and @remi, who have experience with breast cancer and thryoid issues.
Katrina, as you know, everyone is different, and I would talk to your oncologist and pharmacist about possible drug interactions and what adjustments might have to be made for you. Are you taking Synthroid (levothyroxine) since having your thyroid removed?
Replies to "Hi @katrina123, the FDA product monograph states (page 7) https://www.accessdata.fda.gov/drugsatfda_docs/label/2005/020541s016lbl.pdf "In multiple daily dosing trials with..."
Thank you for the information. I will add this question to my list for my next oncology visit.
Yes I have taken the same amount of thyroid medication for almost 50 years.
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I have not had my thyroid removed. But I was taking levothyroxine for over 5 years before I had IDC. I took anastrozole for 12 months then switched to exemestane last November, neither drug effected my thyroid levels. I currently take 88 mcg daily for my thyroid. I have it tested yearly. Good luck and yes discuss it with both doctors. In 2016 I had trouble getting my dosage right, they had to increase it - but you have to take the new dose for 90 days before they know if it worked at that dosage. They changed my dosage 3 times that year. It was frustrating. Long before I had BC - so it may be completely unrelated.