With my Gleason 9 I had prostatectomy September 2010, followed by 32 sessions of adjuvant radiation 3 months later. Side effect was some bladder leakage. Knocked PSA down to undetectable for several years. When PSA started to go up and reached 19 surgeon advised time for chemo followed by Lupron and Zytiga. Went down to .06 with that treatment. I have been on ADT for three years this month. PSA has been holding at .06 to .08. I asked PA how long I might be on this treatment? She just smiled and raised her eyebrows. I told her I took that to mean as long as it kept working and she nodded in the affirmative. Other than lack of Libido I really had no remarkable side effects. Well, maybe a little grumpy now and then and a few hot flashes the first 6 months or so.