Hi @lmcfm1 I recently happened to be looking into this myself for my wife who has peripheral neuropathy. I first heard about it from a discussion on Mayo Connect that talks specifically about it. Here is what I have learned: first of all, naltrexone is a drug that has been used since the sixties to help drug and alcohol addicts with their addictions. It binds to and therefore blocks the endorphin receptors in the brain and therefore does not allow drugs or alcohol to interact with those receptors thus removing the ability for the addict to get high. It is prescribed and administered in 50 mg doses. What @lilotter referred to was low dose naltrexone, which is an off label usage of naltrexone administered in 1.5 - 4.5 mg doses, which must be specially made for you by a compounding pharmacy. . Because it is in a much smaller dose, it works in a much shorter time period (about 4 hours) and is taken before bedtime so that is is active from about 2 hours to about 6 hours after going to bed, thus it is active at a time when your body is normally producing the most endorphins that it does during the 24 hour day, in the middle of your sleep cycle. During this time it blocks the endorphin receptors in the brain which causes the body to try to generate more endorphins to increase the supply which it thinks it is in short supply of. This extra endorphin supply then helps you throughout the day by modulating your immune system as well as helping to reduce inflammation in your body. Many people have benefitted (and a certain percentage have not) with various conditions, such as neuropathy and fibromyalgia. There are a few side effects but they are mostly mild for most people and none seem to be life threatening. One thing, you have to be careful with your diet while taking it as it can lead to an overgrowth in candida albicans (which is no fun, I have dealt with that before). You may need to take it for a few months before you notice an effect. There are some good website with info on it, so do some research. Best of luck. Hank