Hi @laura1965. Great question on weight gain (as a side effect) with Prolia injections. I would like to bring into the conversation @sue225 @contentandwell @migizii who have all had some experience with Prolia. As I was researching this a little, I was able to find the following information on https://www.medicalnewstoday.com/articles/prolia#side-effects

From Website:

Weight gain itself wasn’t reported as a side effect during clinical trials of Prolia. However, some people taking Prolia did have swelling in their arms or legs. And with swelling, your body weight can be quickly increased.
In clinical trials of women who’d gone through menopause and who were taking Prolia for osteoporosis, 4.9% had swelling in their arms or legs. In comparison, 4% of the women taking a placebo (no active drug) had swelling. During studies, people taking Prolia for other conditions didn’t report any swelling in their arms or legs.
If you have weight gain or swelling of your arms or legs while you’re taking Prolia, talk with your doctor. They may be able to recommend ways to help reduce this side effect.
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Have you mentioned this side effect to your provider yet? Have you had any other side effects with Prolia?