Hi Teresa and tsabe2. At this time, I’m not able to provide any input to this discussion on Afinitor because I haven’t yet started this line of treatment. I was scheduled to begin a year ago in April but my oncologist and I decided to hold off as the current meds at that time were keeping my cancer stable. Since then, it has spread to my liver and with that a new set of drugs (Ibrance and Letrozole). Recent scans revealed additional progression of disease on my liver, so once again Afinitor is on the table. Meeting my oncologist next week to decide next steps. Best wishes to you, tsabe2!