My diagnosis was difficult until I hit Mayo. I live in Albuquerque. My primary care sent me to every specialist except an oncologist. Everyone of them said that something was wrong but it wasn’t in their silo. My primary got me into Mayo Clinic. Again, my nasty insurance company was denying my ability to see a Neurologist. I saw a wonderful endocrinologist at the clinic. She said my life was in jeopardy and admitted me to Mayo Hospital. She said once admitted, my insurance company couldn’t deny anything. Within 48 hours the doctors at Mayo diagnosed me. I had many tests. They were on to something when they did the MRI with contrast. My brain had swollen over the hemisphere. Ultimately, I had a brain biopsy to confirm diagnosis. I spent over 3 weeks at the Mayo hospital in Phoenix. I had one infused Chemo and two biologic treatments there. They set up my protocols and found a hemo-oncologist to treat me in my home state. In 2016, I spent over 70 days in hospitals. I can’t tell you how great they are at Mayo. That was way more than you asked...the short answer is brain biopsy! :). My current oncologist says she loves this protocol and thinks the Temodar was a great added to high dose Methotrexate.