@migizii, My husband and I usually stay at the Brentwood Inn on 4th Ave NW. It is clean, quiet, free parking, and has subway access directly to the clinic. An added bonus for us is that it is near the entrance to the Charlton labs where I begin my day.

You might want to contact the free Concierge Service at Mayo Rochester. I used the chat line as I was planning our trip, very helpful with my restaurant questions and other updates that I wanted to know.
Here's how to contact them during Central time business hours.
* Phone: 507-538-8438
* Live Chat: https://www.mayoclinic.org/patient-visitor-guide
* Email: concierge@mayo.edu

In advance, be aware that there is lots of road work in downtown Rochester. . Broadway is closed from 2nd St SW to Civic Center Drive. Detours are well marked

You have made me laugh! Along I-39 in Illinois, there were lighted overhead signs with COVID19 messages. Here is one that I remember reading. "You sure look good in that mask".
A tip that I learned from my opthamalogist here at home was to put a small piece of tape on the underside at the top of nose my homemade mask so it would stay in place when I talked. So I tried it, I took a small piece of some surgical tape and doubled it over so it was sticky on both sides, and It worked! No more slipping down my face.

@migizii I don't know if you need a hotel room with a full kitchen. The hotels within walking distance of the Mayo campuses are usually a bit more expensive. Most of the hotels have a shuttle service (this hotel does too), although I don't want to be on public transportation with other people. If you have a car and can drive yourself to the Mayo parking ramp, I recommend the Townplace Suites by Marriot. The rate for Mayo patients was $99 per day. It is a couple exits north of Saint Mary's Hospital on Rt 52 and St. Mary's is about a mile from the Gonda/Mayo/Charleton buildings. The rooms were clean and fairly large.