My tumor marker also has elevated in the last 6 months-I am at the end of 5 yrs on arimidex for Stage 2 and had a rapid weight gain after I took 2 doses of Prolia so I stopped that. I will now work harder to get weight off and can’t wait for warmer weather, my gym to be able to re-open in 3 weeks (COVID 19). I am a semi-retired nurse that researches everything to death. I used Venlafaxine for the massive hot flashes and it worked perfectly.