@lilypaws I think I belong to this group. I am summertime4. I am over board with frustration stemming from neuropathy, lymphedema, back issues. I do belong to the neuropathy group which is very helpful. My anxiety and depression are wearing me down as much as the pain is. I was diagnosed with depression and anxiety long time ago. I have been on sooo many medications. One I remember being helpful was Zyprexia. I took it for several years and the entire time my head was feeling normal my body was getting heavier and heavier. The weight gain was too unhealthy so I weaned off. It was the worst time I ever had with medication withdrawal. I know it was at least a year of sheer hell. Oh I lost weight 208 down to 145 within 6 months along with the depression. Moving fast forward. I continued with depression and anxiety and was on several medications. I think I stayed on Zoloft for years. Ok-2 years ago my husband died. I bean seeing another provider as I really wasn't seeing a psychiatric nurse and just getting meds from my PCP. I was prescribed Effexor. Didn't do anything but stayed on it, @ months ago I was referred to a psychiatric nurse for medication check. She did Genesight test. Effexor wasn't a good med for me/ Of course I knew that. Very difficult withdrawal from 37.5 Effexor and while withdrawing was prescribed Trintellix. Stopped 2 days ago under doctor's ok. So 3 days no psychiatric meds. Nurse recommended Pristiq. Has anyone taken that? Sounds alot like Effexor. I also looked up