I apologize. I did not read your whole post, but stopped at "punch biopsy". What the heck is that? I've never heard of it. I usually would talk to Mr. Google, but I'm spending too much time on here, lol. Also, I have wondered about the causes of my chronic pain. I do have some degenerative disk/nerve issues--cervical--before injections into the optical lobes of my brain, I often felt like the back of my head was going to explode. I have osteoarthritis here and there, but nothing that explains my chronic allover pain. Sometimes I feel like it would hurt if someone touched my skin, like when you have a high fever, and others my back feels like it is on fire, seriously on fire, but when a doc pushes on it no increased pain. OK, I did just read your entire post. I have never tried or been suggested to try the CBD/THC route. Guess I am still somewhat skeptical.