Sorry to hear. I first had a colonoscopy, which as normal. Then I took a sitz marker test. You swallow a pill pull of radioactive rings and they take xrays to follow the rings through your digestion process. There are different ways to do it. I took an xray, then took one pill, came back 3-4 days later and had the last xray. All of my markers were still in my body. So, they consider this slow transit constipation. I also had an upper scope which was normal. And finally a Defecography, which was normal, and Anorectal Manometry, which indicated i had some Dyssynergic Defecation. I did pelvic floor therapy, including biofeedback, for a year or so with little result. Im considered Chronic Idiopathic Constipation, which is unknown cause. Ive been on Amitiza, Trulance, Linzess now Motegrity.