After using Gabapentin with little relief, Nucynta with great pain relief $700/mo and Cymbalta with memory loss, I started with Lyrica. Over time, my Rx was adjusted to 2.25 2x daily. Other than slight dizzy feeling, I have had no negative effects. I have plantar fasciitis, arthritis in all joints, and serious neuropathy up to thighs and my fingers. Lyrica and Tramadol generally keep pain manageable—some days much worse. When it is wearing off, the pain goes up. And, if I am even one hour late taking the combination, the pain intensifies greatly and quickly. One note; the fiery feeling on top layers of skin is not well-controlled. I use a CBD ointment, which calms that down almost immediately and last for about 5 hours.