Hello @rwinney. There is some information out there about plasmapheresis (also referred to as plasma exchange), but the research I am finding has to do with neuropathy in relation to specific causes. For example, here is a research study from the NIH, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1027944/. They use plasma exchange for patients dealing with a plasma cell dyscrasia. Here is another article where multiple types of neuropathy are discussed, https://jamanetwork.com/journals/jamaneurology/fullarticle/791917. It looks as though there are differing circumstances and causes that lead patients to this type of treatment. Has this been discussed as an option for you?