@cschultz8 I had stem cell therapy, a set of three with first PRP (plasma rich platelets, spun out of your own blood), then stem cells made from my own fat cells (unpleasant but not painful scraping process for 40 minutes while inhaling laughing gas), the PRP again. It worked great for two years. I'm over 65 and also had bone-on-bone. Pain not totally gone but for all practical purposes gone. Then I fell hard and my knee got hit very badly. I could have tried the stem cells again but the problem is no insurance will cover it, and uncertainty. So I went with Makoplasty TKR. I'm a bit over two months out and not yet willing to give a final statement on how successful that was. My cost for the three procedures (PRP and stem cells) was close to $8,000. If the cost is not prohibitive to you, it's worth a try. Make sure you get a very competent and reliable provider to do this, as there are many scams out there. A good doctor will tell you if you are not a candidate. Certainly the recovery is much easier than for TKR! Best of luck.