I had my first 6 month Lupron shot in Oct and started Zytiga on Dec. 2nd. My PSA dropped to ( .1 ) No major problems, mainly just hot flashes at times that don't last very long and of course no sex drive at all. Lucky for me my wife and I have a great relationship and she would like to keep me around, lol. I'm having a bone density test in Feb sometime to track any possible bone loss. No other real problems, thankfully. The 5mg of Prednisone that goes with the Zytiga have helped my Parkinson's issues and made me feel much better overall. So far so good, keeping my fingers crossed.