My wife has early onset Alzheimers and her neurologist put her on Donezapil. He keeps reiterating that my wife needs to be on this med because if she stops taking it, she will quickly regress to where she would have been without the drug. That scares me so I make sure she doesn't miss a dose. However, I have also read and have been told by the same neurologist that it does not slow the progression down but rather helps with symptoms. I have heard that curcumin helps with slowing the disease and according to one doctor reverses the disease. In discussing this with my wife's neurologist, he said if that were true, he would refer everyone of his patients that direction. So, I don't know if meds do anything or not. I am just going to go with what the professional says. He seems to know his stuff. Yet, having said that, there is a ton of potential side effects to the med.