Hi, @aliali – sounds like you've been through a number of medication switches with your major depressive disorder. I also have depression, but have not had to switch in a number of years. I do recall, however, that it's tough to switch from one med to another. I have not personally had the experience of switching from a generic to a brand name of an antidepressant or an antianxiety medication. My movement with medications has generally been to a different med or from generic to brand name.