25 mgs. At bedtime. I started at 12.5, then went to 25. I stopped taking it to make sure it was helping with a very specific pain caused by a combination of neuropathy and heavy duty compression of my left leg and foot. It was very helpful so i decided to try 50mgs. Too much. I went down to 37.5 but still too much. Larger doses made me too sleepy even though I took it at night. This was pain that Lyrica did nothing for. I tried dropping each of my meds, one at a time to make sure I really needed them. Amitriptyline is a winner for me. Doesn't hurt that is an antidepressant either. I also like it because it's a sleep aid and my compression can be quite uncomfortable at night and it helps me sleep through. I have lymphedema on my left side because I had 21 lymph nodes removed during cancer surgery.