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Thyroid Cancer Group: Introduce yourself and connect with others

Thyroid Cancer | Last Active: 2 days ago | Replies (173)
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@colleenyoung

Hi @danielad, that is a question outside of my knowledge. I couldn't find much about low levels either.

However I found this information by Mayo Clinic Laboratories:
- Parathyroid Hormone-Related Peptide, Plasma https://www.mayocliniclabs.com/test-catalog/Clinical+and+Interpretive/81774
As you noted, it is an elevated level of PTHrP that can indicate a need for further investigation for a malignancy.

Of particular note are the last two sentences
"Like all immunometric assays, PTHrP assays are susceptible to false-low results at extremely high analyte concentrations ("hooking") and to rare false-positive results due to heterophile antibody interference. Therefore, if test results are incongruent with the clinical picture, the laboratory should be contacted."

You said that this was the first time that your PTHrP was tested. Is it possible that is was a false low?

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Replies to "Hi @danielad, that is a question outside of my knowledge. I couldn't find much about low..."
Dee | @danielad | Jun 23, 2020

@colleenyoung -- Thank you Colleen. Yes, I read the same article and wondered if mine was a "false-low" result. I didn't think the doctor was prepared to discuss the issue with me, so that's possibly why he initially told me he was ordering the "Sestamibi scan".

Thanks Colleen!

--- Dee

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Dee | @danielad | Jun 24, 2020

@colleenyoung -- Colleen, I wonder if there may be a "better suited" group for my question? I guess I could create one by establishing an "ENDOCRINOLOGY" group. It could be the "umbrella" group for a number of different endocrinology-based medical issues or questions?

Different question: The Nephrologist has ordered labs for Aug (2-months check-up) which do NOT include a repeat test for the PTHrP. I think I should ask him to add it. What are your thoughts on that?

Thanks!!
-- Dee

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