Hi John, This subject came up a few months ago and it caught my eye, as I was taking a CBD tincture at bedtime. The discussion, as I recall suggested that this was not necessarily a good therapy while taking Prednisone. The person seemed to know that the pathways that both CBD and Prednisone use are similar, so that it was contraindicated to combine the two. Do you recall this? I can't find the discussion, there are quite a few strings on PMR and related aspects of the condition, a lot to sift through. Anyway, I stopped taking my CBD tincture and haven't looked back. I've been able to very slowly taper my prednisone but still at 9 mg. If anyone knows the person/string that addressed this, please remind me. thanks. Karen