I dont believe I took prednisone with food. I took it once a day for 20 months many of those below 5

I never took mine with food either but I would encourage people to do that because that was recommended. I did drink plenty of water when I took prednisone. I think PMR is now in remission for me after 12 long years --- at least I have been off prednisone for the past 4 months.

I have some theories about PMR that seems to make sense to me. I don't know what triggered PMR but for me everything points to an adrenal/cortisol problem. I have read about cortisol and how the HPA axis is supposed to work. For me, that seems to be the mechanism that is faulty. Cortisol is called the "stress hormone" and the HPA is supposed to regulate inflammation. To me, it makes sense to take prednisone. However, taking prednisone disrupts how the HPA axis is supposed to work --- there are many circadian rhythms that are disrupted based on how prednisone is dosed. There is no oral dosing pattern that duplicates how the HPA axis functions.

I personally, took prednisone between 3 and 4 am because that was when I woke up with pain and stiffness. If I didn't take it by 4 am, there was no way I would be ready to go to work by 7 am.

I have heard about fasting for other autoimmune diseases in order to stop the pain. Presently, I am interested in eating healthy and any eating pattern that helps me to lose weight.

I have taken prednisone and blood pressure medications basically when I get round to doing it, sometime in the morning. Like you have never had stomach irritation. However there is one drug for blood pressure that says don't eat grapefruit. Well I once worked in a place that had a grapefruit tree and I couldn't resist ... silly yes .... felt quite sick for the rest of the day.