Hi Chris, sorry to hear of your difficulties. I am similar age to yourself and also had rapid, overnight actually, onset of PMR. I am wondering if shock plays a part in this. Your colonosopy and the medication in your case, and in my case spending a couple of days with my ex husband and finding he had extreme paranoia all of a sudden living in fear of intruders, etc. Plays with your mind for sure. Anyhow I rapidly got onto prednisone at 15 mg a day and 16 months later got myself down to 2 and a half but in view of this pandemic cutting down to one one day, one and a half the next, for sake of immune system. Just holding the stiffness at bay. You ask about fatigue. Its a funny thing, comes and goes. Mine is more just sometimes my eyes shut and I drift off in company, or wherever. Kids just put it down to old age lol.It will last a day, then ok for a week perhaps. Its stayed the same from before diagnosis til now on very small amount of prednisone. Take Care in these difficult times.