Hi @ajp2019, I see this is your first post and would like to welcome you to Connect. I have PMR but it's currently in remission so no longer need to take any prednisone. When I was diagnosed I was started at 20mg dosage and took it in the morning. We are all different when it comes to the pain symptoms and I'm pretty sure there are other members here that have split their dosage into a morning/evening time frame. Did you just start taking prednisone or about to start it for your PMR? I would run it by your rheumatologist but think it depends on your pain level from the PMR.