Hi @ajp2019, I see this is your first post and would like to welcome you to Connect. I have PMR but it's currently in remission so no longer need to take any prednisone. When I was diagnosed I was started at 20mg dosage and took it in the morning. We are all different when it comes to the pain symptoms and I'm pretty sure there are other members here that have split their dosage into a morning/evening time frame. Did you just start taking prednisone or about to start it for your PMR? I would run it by your rheumatologist but think it depends on your pain level from the PMR.

I take all mine in the morning midway through breakfast. Have had no issues of insomnia after the first week at 20mg.

If taking your dose all at one time works, do that. I now take my 10 in a split dose with 7.5 or 8 in the morning and 2 or 2.5 in the evening. Each of us is different so it pays to experiment, but once or twice a day is typical.

I started on a daily dosage and almost within a week my pain level went through the roof. Splitting my dosage during the day was a game changer for me, although my split was a morning vs evening dosage. Looking back, I think my doctor initially started me at a single daily morning dosage because of prednisone's impact on sleep. After the split, pain largely disappeared, but sleep quality did too, which has been a fair trade.