I, too, will be interested in Colleen's reply. I have been having gum problems as well over the past two years (since the initiation of anastrozole). I have been attributing it to not tolerating blood pressure meds (my PCP has changed it 6 times in the past two years). This month, I have been wondering about the anastrozole being behind it. Since September, I have acquired osteoarthritis in my hands, Trigger Thumb, and lost a half-inch in height… all in three months. I have read that AIs can promote arthritis and Trigger digits (and carpal tunnel syndrome which I had last year), and the orthopedic hand specialist I consulted noted that the anastrozole could be at play. Tomorrow I see a spine specialist for the height issue (and aching back). What a trade-off…!