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@cfacarol

Thank you for the link, I had not seen this article. I do not have a scientific background. Most of the article was extremely complicated and I did not read it in great detail. The Conclusion (section 8) does state that although a lot of studies have been done, there is no evidence to date between low estrogen and cognitive change and that more research is needed. Perhaps I am missing something.

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@cfacarol
This particular study sought to find inflammation as a mediator of low estrogens and cognitive changes, and notes that there is no empirical evidence for that. However, throughout the article, it notes that their search found numerous studies demonstrating that chronic low E2 levels are associated with cognitive impairments in both human and animal studies.