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Cancer Related Brain Fog: How do you cope with it?
Cancer: Managing Symptoms | Last Active: Nov 11, 2023 | Replies (52)Comment receiving replies
Is there any empirical evidence linking estrogen loss from AIs to cognitive function? I have not been able to find anything. I have been faithfully taking my letrozole for 5 months and seem to be confused and forgetful a lot, but maybe it’s because I just generally feel lousy.
Replies to "Is there any empirical evidence linking estrogen loss from AIs to cognitive function? I have not..."
@cfacarol
There are plenty of studies on the effects of reduced estrogen via natural and surgically-induced menopause, and we can lump ourselves into the larger pie. So, yes... estrogen loss from AIs does effect our cognitive function (it's not your imagination). Here's a good article from the Frontiers of Neuroendocrinology: https://www.sciencedirect.com/science/article/pii/S0091302216300024
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The presenter at this session did not talk to effect of any medications on cognitive function. I am taking a break from AI (with permission of oncologist) to see if I see any changes with cognitive and fatigue issues.
I did check https://www.ncbi.nlm.nih.gov/pubmed for any published studies on hormone therapy and cognitive issues, there are some published studies. I tried reading some, but very technical and not sure if there was any conclusion.
Laurie