Hello everyone. My husband was diagnosed In July of 2018 with cancer in the pancreas tail with metastases to the liver in addition to veins around the spleen. We came to Mayo hoping it might be operable, or failing that, eligible for a clinical trial. The trial drug, along with Abraxane and Gemzar stopped working after 9 months. Then he began a regimen with 5 FU. Now I am afraid resistance is again setting in. Even though the last scan did not show progression, his CA 19-9 has begun to rise and his ascites are accumulating at an ever faster rate. He has to have them drained every 10-14 days. The last progress notes mentioned speaking to us about a biopsy on his next visit. I am hoping for better news, but fearing the worst. Stories of hope are most welcome!