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@mnmom

I have tried a bunch of different anti depressants and other meds over the years, some aimed at anxiety, some not, with varied results. Prozac was good for me to a certain degree, but didn't address the anxiety. Buspar was awesome, but I was dizzy for hours with each dose, so discontinued. Wellbutrin made me hostile (to put it mildly), which is especially bad for me because my anxiety comes out as agitation, irritability, and feeling like I'm possessed by a rage demon. So that was a no go. Lithium did nothing for me at all. Depakote didn't help my mood, and I gained 100 pounds. Tegratol- rash. Lexapro- kind of worked, but not well enough. I'm sure there were more, but that's what I remember off the top of my head. The real game changer for me? Effexor. It is tough to get on or off of (have to ramp up and taper off very planfully), but it isn't an exaggeration that if I'd found it 30 years ago, my life would have taken a very different path in many ways. It pairs well with my adderall as well, and I haven't had any side effects after my body adjusted to it (took a few weeks). Once it did, I swear it was like clouds parted and the choirs sang and I realized what it was like to not feel crazy/on edge/etc and could actually THINK, learn and implement new skills and tools, and move forward in my life and relationships. Everyone is so different that it's hard to tell what direction to go in, but I would strongly encourage you to advocate for yourself in finding the right med/combo of meds. Don't stop searching until you find a med/combo/dosage that is just right for you. "I feel better than I did" is a START, not the finish line. Good luck!

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Replies to "I have tried a bunch of different anti depressants and other meds over the years, some..."

Hi, @mnmom – sounds like you've had a variety of experiences with different antidepressants over the years, and you've experienced some ups and downs in this process.

You might be interested in looking at and contributing to Mayo Clinic Connect discussions on some of the medications you've tried for depression, such as:

-On fluoxetine (Prozac) https://connect.mayoclinic.org/discussion/all-about-prozac/

– On escitalopram (Lexapro) side effects https://connect.mayoclinic.org/discussion/horrible-lexapro-side-effects-not-going-away/

-On starting (buproprion) Wellbutrin https://connect.mayoclinic.org/discussion/starting-wellbutrin/

For what condition do you take dextroamphetamine-amphetamine (Adderall)?

Darn! Lexapro made me so sick I thought I was dying. Couldn’t make it after the fourth day. Glad it works for you and others!

Hi, @mnmom – thinking of you. How are you doing lately? Is the venlafaxine (Effexor) still working well for you?