Hello @vfaye. You may notice I combined your discussions on low dose naltrexone to one discussion and moved it to the autoimmune diseases group where the other PMR discussions are located. @vfaye, here is some additional information on naltrexone and its possible uses, https://www.mayoclinic.org/drugs-supplements/naltrexone-oral-route/before-using/drg-20068408. There are some counter-indications listed for this medication and it does mention it should be prescribed by a medical provider and they can help decide the best regimen moving forward. Is this a medication that you have discussed with your provider?