I'm a Lupron user for the past two years and feel quite blessed that my issue is being managed quite well to this point. I receive an injection every 6 months. Very little side effects with the Lupron, some hot flashes, which have reduced in frequency over the 2 year period, and possibly experiencing some cognitive issues but that could possibly be an age related problem, I'm 78. PSA has been staying less than 1. I do exercise fairly vigorously 2-3 times a week and do other activities most other days. I'm in good health and have maintained my weight, approx170# for the last 10+ years. Also maintain sensible eating habits. Have discussed Zytiga as possible course if PSA begins to rise so have an interest in its cost, side effects and efficacy. Predisone will be part of the Zytiga treatment. Has Zytiga gone generic? Have had prosecetomy, 2010 , radiation and chemo over the years buy only Lupron when PSA started going up about 4 years ago. Just recently started taking Alendronate, the generic for Fosamax, for bone health. Last scans about 6 months ago look fairly clean some evidence of metastasis but that has remained unchanged for last 2-3 years. I would like to remain part of this conversation and will contribute any info I can. Thank you all and best of success in you courses of treatment.