I have recently been diagnosed with multiple Auto immune disorders (like back to back). I have also had ton of tests, blood work, and specialists this past year but decided to see a functional medicine doctor last month. She spent 3 hours with me and my detailed symptoms. She ordered several non-conventional tests including heavy metal levels and EBV. May be worth a try for your wife. Functional medicine doctors are focused on root cause of illness so may be a good adjunct to what you are already doing. Hope that’s helpful! Prayers for your wife!!