Hi,
That was a question I had when I started the big 3 as well. I developed ototoxicity after about 6 months on the medication. One day I woke up to terrible tinnitus (on testing, I also had some hearing loss). It was likely from the azithromycin but I stopped everything.

That was 2 months ago and I’m still off the medications and continue to be fairly well, using a nebulizer with saline every morning, followed by a number of lung clearing exercises and use of an Aerobika.

Good luck to both of you!