Hello @curtj, I would like to add my welcome to Connect along with @artscaping and other members. It sounds like your wife's doctors have not been able to come up with a diagnosis or treatment plan. Have you thought about seeking help from Mayo Clinic where medical experts work in multidisciplinary teams across different specialties? If you would like to seek help from Mayo Clinic, you contact one of the appointment offices. The contact information for Minnesota, Arizona and Florida can be found here http://mayocl.in/1mtmR63.