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Calcium and Vitamin D for bone density

Osteoporosis & Bone Health | Last Active: Jan 29 8:02am | Replies (340)

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@julie2020

Thank you for your info regarding Forteo and the osteosarcoma study. My doctor has recommended this for me. May I ask your age and also what were your osteoporosis levels before and after Forteo?

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Replies to "Thank you for your info regarding Forteo and the osteosarcoma study. My doctor has recommended this..."

Of course! I am now 66. Except for polymyalgia rheumatica right now I have enjoyed good health my whole life. I am 5' 2" tall and keep my weight as close to 120 as I can. Smallish person. I was diagnosed, to my horror, with severe osteoporosis in Oct. 2014. When I was diagnosed my T-score was -3.3 at the lumbar spine. My endocrinologist put me on monthly Boniva, a bisphosphonate, which was (and is) considered a first line of defense drug. In Nov. of 2016 my Dexa scan lowest score was -2.1.
I stopped Boniva and started Forteo (real name teriparatide) in Dec. of 2016. In 2018 my Dexa scan score was -1.1 at the lumbar spine, osteopenia and close to normal. In total, I stayed on Forteo for 2 years plus a few months (the pens have more than a month's doses in them) because that is the time limit for Forteo. So Boniva helped, but Forteo put me over the top (almost!).
I read, sadly and too late, that bone health and strength benefits from a teriparatide-first, bisphosphonates second treatment. Bisphosphonates like Boniva are the first line because they are cheap and easy to use (a pill once a month in my case). Forteo is expensive and requires daily shots in the thigh.
There is a third option and that is SERMs - selective estrogen replacement modulators - which have a different mechanism of action. The use of SERMs for osteop. was discovered when it was shown that women who took the drug to reduce the risk of invasive breast cancer also had less osteoporosis. Risks attached to this as well, most notably deep vein thrombosis. Brand name Evista (raloxifene).
Since the black box warning on Forteo has been removed I am hopeful that if I need to go back on it I will be able to. This hope has been expressed to me by my new rheumatologist recently. He is treating me for PMR.
From what I have read, Prolia (denosumab) is to be avoided. Multiple spinal fractures on stopping this drug due to rapid bone loss. https://pubmed.ncbi.nlm.nih.gov/30659428/#:~:text=After%20the%20second%20denosumab%20dose,%20there%20is%20a,uncertainties,%20denosumab%20is%20a%20second-line%20treatment%20for%20osteoporosis. Other risks as well.
I am glad to be able to share my story with others and am grateful for forums like this one that allow us to share and learn from each other! I learned a lot from the National Osteoporosis Foundation's forum at insire.com as well. Look up "my journey with Forteo" -- it is fascinating, by a contributor named "hocadobi."
Good luck and bone blessings and health to you!