Hi Joanne, I think the only way you would know for sure of the effects of the PEA, would be to start eliminating each of the others, one at a time, or all together, and see what happens to your body just on the PEA. I don't even think a pharmacist would know for sure, because they study drugs, much more than supplements. Were all these supplements, taken all together, (including the PEA) helping before, and for how long? It is so darn sad what we go through to try to feel well. I just couldn't take another moment of feeling the burning in my feet. It was like, "What the hell is this already?" I did not feel like tapping pain away, telling myself I am well, and don't need pain signals; yada, yada, yada. So, I just smoked a reefer. Like I am 20 again! And this is so exceedingly crazy. Smoking grass to not feel pain. I could never have imagined my life would come to this. Like the Devil's joke. I don't know anymore. I just don't know..... Lori Renee