My husband did not have symptoms. The cyst in the head of the pancreas was found incidentally on scans done while he was hospitalized last January for diarrhea, dehydration, kidney function etc etc that was eventually treated as Colitis.He was referred to a GI doc who confirmed local findings and then referred to Mayo because of troubling aspects of the cyst in the main duct and branches—size, nodules, thickening of walls. A biopsy prior to surgery came back negative, but in surgery pathology confirmed that the cyst had transformed into a malignancy. I have followed @marvinjsturing comments previously.