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Ideas for pain relief from Small Fiber Neuropathy (SFN)

Neuropathy | Last Active: Apr 26 7:21pm | Replies (449)

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@burningfeetinphoenix

@burningfeetinphoenix here...I have been researching personalized stem cells as a way to deal with SFN. I came across a paper published in January 2019 outlining this potential technique for helping with SFN burning pain. This is the name of the paper: "Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors". Has anyone heard of or researched this potential treatment? Pam

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Replies to "@burningfeetinphoenix here...I have been researching personalized stem cells as a way to deal with SFN. I..."

Hi @burningfeetinphoenix -- I found the paper and it does sound promising but the caveat is that only one person was involved in the test which leaves a lot missing.

Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors
-- https://www.ebiomedicine.com/article/S2352-3964(18)30546-2/fulltext

It's also referrenced by NCBI here -- Pain relief in a neuropathy patient by lacosamide
-- https://www.ncbi.nlm.nih.gov/pubmed/30503201
"FINDINGS: We identified patient-specific changes in iPSC-derived nociceptor excitability in MEA recordings, which were reverted by the FDA-approved compound lacosamide in vitro. Using this drug for individualized treatment of this patient, the patient's pain ratings decreased from 7.5 to 1.5. Consistent with the pain relief reported by the patient, microneurography recordings of the patient's single nerve fibers mirrored a reduced spontaneous nociceptor (C-fiber) activity in the patient during lacosamide treatment. Microneurography recordings yielded an objective measurement of altered peripheral nociceptor activity following treatment."

What is the difference between small fiber neuropathy and peripheral
neuropathy?