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DiscussionIdeas for pain relief from Small Fiber Neuropathy (SFN)
Neuropathy | Last Active: Apr 26 7:21pm | Replies (449)Comment receiving replies
Replies to "@burningfeetinphoenix here...I have been researching personalized stem cells as a way to deal with SFN. I..."
What is the difference between small fiber neuropathy and peripheral
neuropathy?
Hi @burningfeetinphoenix -- I found the paper and it does sound promising but the caveat is that only one person was involved in the test which leaves a lot missing.
Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors
-- https://www.ebiomedicine.com/article/S2352-3964(18)30546-2/fulltext
It's also referrenced by NCBI here -- Pain relief in a neuropathy patient by lacosamide
-- https://www.ncbi.nlm.nih.gov/pubmed/30503201
"FINDINGS: We identified patient-specific changes in iPSC-derived nociceptor excitability in MEA recordings, which were reverted by the FDA-approved compound lacosamide in vitro. Using this drug for individualized treatment of this patient, the patient's pain ratings decreased from 7.5 to 1.5. Consistent with the pain relief reported by the patient, microneurography recordings of the patient's single nerve fibers mirrored a reduced spontaneous nociceptor (C-fiber) activity in the patient during lacosamide treatment. Microneurography recordings yielded an objective measurement of altered peripheral nociceptor activity following treatment."