@burningfeetinphoenix asks: Has anyone looked at the research being done on Capsaicin for SFPN? I found this report just published in "Pain Reports" published by scientists in France. I cannot post the link in the forum but I am posting the name of the article and it can be accessed on-line. I have severe to moderate sweat glands in the feet and legs as well as severely reduced small epidermal nerve fiber density in these same places (detected by proximal and distal skin biopsies). The research on the mechanisms causing the heat sensitivity and other symptoms is interesting and often difficult to understand. However, it has helped me zero in on my SFPN and I am continuing to learn a lot about my condition. Here is the name of the article: "Functional and histological improvements of small nerve neuropathy after high-concentration capsaicin patch application a case study". Bu Trouvin, Anne-Priscillea and Perrot, Sergea. There have been clinical trials using the cream version of Capsaicin and these studies were not as promising..Chloride conduction seems to be a key factor in small fiber nerve function and growth... I will continue to research and report back... Pam